The two clubs played out a thrilling 2-2 draw in Spain last week to leave the tie evenly poised at the halfway point.
United played well at the Camp Nou seven days ago and were disappointed not to come away with an advantage on aggregate, having recovered from a goal down to lead, only to concede an equaliser 14 minutes from time.
Here is your briefing ahead of this evening’s game, with a place in the Round of 16 awaiting the winners.
What time does Manchester United vs Barcelona kick-off?
The game will kick-off tonight (Thursday, February 23) at 8pm.
With the away goals rule not in use, the match will head to extra-time and if required, penalties, if the scores are level after 90 minutes.
How to watch on TV and live stream
Manchester United vs Barcelona will be shown live on BT Sport 2 and BT Sport Ultimate.
Programming will begin at 7pm on both channels.
Those with a BT Sport subscription will also be able to stream the game live via the BT Sport app and web player.
Fans without BT Sport will still be able to watch the match by purchasing a monthly pass for £29.99, which provides 30 day access to all four channels via the app and web player.
How to listen on radio
BBC Radio 5 Live will have exclusive radio coverage of the fixture in the UK, with the build-up starting at 7pm.
When is the Europa League Round of 16 draw?
The draw for the next round will be held tomorrow (Friday, February 24) at 11am.
The winner of tonight’s tie will be drawn against one of the eight Europa League group stage winners.
The first legs are scheduled for Thursday, March 9, with the return legs set for Thursday, March 16.
MORE : Why are Arsenal not playing in the Europa League this week?
MORE : How to watch the Europa League on TV and live stream in the UK
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