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The 27-year-old has been in sublime form for Stuttgart this season with 16 goals in 10 appearances so far.
United remain in the market for a new striker to ease the burden on £72 million summer signing Rasmus Hojlund, who is yet to score in nine Premier League appearances this term.
Newcastle, meanwhile, have been hampered by injuries to both Alexander Isak and Callum Wilson at different stages this season.
According to FootMercato, United, Newcastle, Roma and AC Milan have already enquired about the prospect of signing Guirassy in the upcoming transfer window.
The report claims Guirassy would be open to leaving Stuttgart in January, while the striker is available for a modest fee due to the €17.5 million (£15m) release clause in his deal with the Bundesliga club.
Speaking at the weekend, Stuttgart manager Sebastian Hoeness conceded that Guirassy could leave in January.
‘In football you can never exclude anything, so I won’t do that here either.
‘I think he feels really comfortable. Of course, I hope he stays with us for a long time, just has a good time with us.
‘But with him and with the others, it is never possible to exclude things.’
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