Pep Guardiola’s team have been in imperious form this season, sitting in second place just one point behind leaders Arsenal.
Manchester United have recovered well since their disastrous 4-0 defeat against Brantford, stringing together four consecutive victories in the Premier League under Erik ten Hag.
But new-look United will be severely tested at the home of their city rivals despite a respectable record at the Etihad, who are looking well set for a third league crown in a row.
Here is your briefing ahead of the Manchester derby.
What time does Manchester City vs Manchester United start?
Manchester City vs Manchester United will take place today (Sunday, October 2).
Kick-off will be at 2pm.
How to watch on TV and live stream
The Manchester derby will be shown live on Sky Sports Main Event and Sky Sports Football.
Sky customers can stream the match live on the Sky Sports website and on the Sky Go app.
Sky Q and Sky+ customers can add Sky Sports Premier League and Sky Sports Football to their existing deals for an extra £18 a month.
Live radio commentary of the game will be on BBC Radio 5 Live.
What is the team news?
The hosts will be without defender John Stones, who was withdrawn from the first half of England’s Nations League game with Germany with a hamstring injury.
Three Lions teammate Kalvin Phillips remains sidelined with a shoulder injury, and it is not expected the midfielder will return until November at the earliest.
Manchester United are set to be without Anthony Martial for the clash at the Etihad, with the French striker struggling with an achilles injury since mid-August.
Marcus Rashford picked up a muscle strain in United’s 3-1 victory over Arsenal before the international break and is a doubt for the match, with Rashford missing England’s final two Nations League group games.
This could open the door for Cristiano Ronaldo to start having been dropped from ten Hag’s preferred XI in recent weeks.
Harry Maguire is likely to miss the match with a thigh strain sustained against Germany.
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